This study investigated bacterial isolates from skin infections, their antibiotic resistance, and the antibacterial activity of honey, plant extracts, and fig milk, including their synergistic effects with antibiotics. Results showed that Staphylococcus was the predominant Gram-positive isolate, while Dermacoccus nishinomiyaensis and Kytococcus sedentarius were identified as opportunistic pathogens. Gram-negative isolates included Enterobacter cloacae, Acinetobacter baumannii, and Stenotrophomonas maltophilia. All isolates exhibited multidrug resistance, with complete resistance to fusidic acid and ampicillin, but remained susceptible to levofloxacin. Honey effectively inhibited Gram-positive bacteria, and alcoholic plant extracts particularly pomegranate peel showed strong antibacterial activity, while fig milk displayed moderate effects. Synergistic assays demonstrated that natural products enhanced antibiotic efficacy, with pomegranate peel extract exhibiting the strongest synergy.