Bacterial resistance to antibiotics is a global threat that drives the continuous development of new treatment strategies due to the rapid and increasing emergence of this resistance. The current study aimed to find the synergistic effect of siderophore extract with antibiotics to overcome antibiotic resistance.

The results showed the ability of (K. pneumonia, E. coli 1, E. coli 2, E. coli 3 S. aureus 1, S. aureus 2) isolates to produce siderophore, also results showed that different siderophore extracts had a different inhibitory effect on the growth of the studied isolates. The results of synergistic effect showed that all the isolates have different responses depending on type of studied isolates as for P. mirabilis isolate, the results of all extracts showed clear synergy with the Trimethoprim-Sulphamethoxazol (SXT), ranging between (11-21 mm), while the synergistic results on S. aureus 3 was noted that Penicillin (P) showed synergy with all extracts, with inhibition zone between (10-15 mm). E. coli 4 showed less synergistic activity ranging between (1-8 mm).