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VOL. 5, ISSUE 2 (2023)
Role of plasmid content in resistance of some enterobacteriaceae species to antibiotics, heavy metals, and biocides
Authors
Sameer M Khalaf, Muhsin A Essa
Abstract
Plasmids play an important role in the
development of antimicrobial resistance by bacteria, particularly
Enterobacteriaceae. This study was carried out to demonstrate the relationship of plasmid
content to the resistance of some Enterobacteriaceae (E. coli O157.H7,E.
coli, K. pneumonia, and S. marcescens ) to antibiotics, heavy
metals, and biocides. All isolates were subjected to plasmid profiling
and curing as well as sensitivity testing towards antibiotics, heavy metals,
and biocides before and after curing. The results showed that all the isolates were multi-drug resistant and
showed high resistance against studied antibiotics, heavy metals, and biocides.
all the isolates contained plasmids, where the largest share of K.
pneumoniae was with three bands, with one band present in all remaining
isolates, After curing, K. pneumoniae lost two plasmid bands, while
other isolates lost their single plasmid band. the results showed a clear
variation in the patterns of susceptibility to studied antimicrobials pre and
post-curing, as this indicates the strong relationship of the plasmid to the
their resistance, results also showed the presence of a combination of
antibiotic, heavy metal, and biocidal resistance genes on plasmid of studied
isolates especially for K. pneumoniae.
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Pages:7-11
How to cite this article:
Sameer M Khalaf, Muhsin A Essa "Role of plasmid content in resistance of some enterobacteriaceae species to antibiotics, heavy metals, and biocides". International Journal of Biotechnology and Microbiology, Vol 5, Issue 2, 2023, Pages 7-11
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